The brand will eventually shift from bottling sourced whiskey to producing it all in-house.
High-rollers can spend up to $2,500 for a gold-plated Julep Cup. All proceeds support the Kentucky Derby Museum.
She leaves Morrison Bowmore Distillers after five years working with brands like Laphroaig, Bowmore and Auchentoshan.
Barrell will make its own whiskey, in addition to bottling limited-edition batches of sourced whiskey and rum.